Wayne State University

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School of Medicine

Biochemistry

Sharon Ackerman

Sharon Ackerman

Associate Professor

sackerm@med.wayne.edu

313-577-8645

Sharon Ackerman

Position Title

 Associate Professor

Education

Ph.D., New York University, NY, NY, 1987

Graduate

 Accepting new MS students in 2023: No
Accepting new PhD students in 2023: No

Office Location

4213 Scott Hall

Research

Dr. Ackerman's research involves mitochondrial oxidative phosphorylation with emphasis on the ATP synthase enzyme.

Publications

  • Sellem, CH, Di Rago, JP, Lasserre, JP, Sharon H Ackerman, Sainsard-Chanet, A: “Regulation of Aerobic Energy Metabolism in Podospora anserina by Two Paralogous Genes Encoding Structurally Different c-Subunits of ATP Synthase”, PLoS Genet., 12: e1006161, 2016.
  • Clark GW, Ackerman SH, Tillier ER, Gatti DL: “Multidimensional mutual information methods for the analysis of covariation in multiple sequence alignments”, BMC Bioinformatics, 15:157, 2014.
  • Tetaud E, Godard F, Giraud MF, Ackerman SH, di Rago JP: “The depletion of F₁ subunit ε in yeast leads to an uncoupled respiratory phenotype that is rescued by mutations in the proton- translocating subunits of F₀”, Mol Biol Cell, 6:791-9, 2014.
  • Kabala AM, Lasserre JP, Ackerman SH, di Rago JP, Kucharczyk R: “Defining the impact on yeast ATP synthase of two pathogenic human mitochondrial DNA mutations, T9185C and T9191C”, Biochimie, 100:200-6, 2014.
  • Ackerman, SH, and Gatti, DL: Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the hydrolysis reaction, PLoS One 8(1):e55136, 2013.
  • Ackerman SH, Tillier ER, Gatti DL: Accurate simulation and detection of coevolution signals in multiple sequence alignments, PLoS One 7(10):e47108, 2012.
  • Ackerman SH, Gatti DL: The contribution of coevolving residues to the stability of KDO8P synthase, PLoS One. 6(3):e17459, 2011.
  • Kucharczyk R, Ezkurdia N, Couplan E, Procaccio V, Ackerman SH, Blondel M, di Rago JP: Consequences of the pathogenic T9176C mutation of human mitochondrial DNA on yeast mitochondrial ATP synthase, Biochim Biophys Acta.- Bioenergetics, 1797(6-7):1105-12, 2010.
  • Meulemans A, Seneca S, Pribyl T, Smet J, Alderweirldt V, Waeytens A, Lissens W, Van Coster R, De Meirleir L, di Rago JP, Gatti DL, Ackerman SH: Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model, J Biol Chem. 285(6):4099-109, 2010.
  • Ludlam A, Brunzelle J, Pribyl T, Xu X, Gatti DL, Ackerman SH: Chaperones of F1- ATPase, J Biol Chem. 284(25):17138-46, 2009.
  • Ackerman SH, Tzagoloff A: Methods to determine the status of mitochondrial ATP synthase assembly, Methods Mol Biol. 372:363-77, 2007.
  • Ackerman SH, Tzagoloff A: Function, structure, and biogenesis of mitochondrial ATP synthase, Prog Nucleic Acid Res Mol Biol. 80:95-133, 2005.
  • Lefebvre-Legendre L, Salin B, Schaëffer J, Brèthes D, Dautant A, Ackerman SH, di Rago JP: Failure to assemble the alpha 3 beta 3 subcomplex of the ATP synthase leads to accumulation of the alpha and beta subunits within inclusion bodies and the loss of mitochondrial cristae in Saccharomyces cerevisiae, J Biol Chem. 280(18):18386-92, 2005.
  • Hinton A, Gatti DL, Ackerman SH: The molecular chaperone, Atp12p, from Homo sapiens. In vitro studies with purified wild type and mutant (E240K) proteins, J Biol Chem. 279(10):9016-22, 2004.
  • Hinton A, Zuiderweg ER, Ackerman SH: A purified subfragment of yeast Atp11p retains full molecular chaperone activity, J Biol Chem. 278(36):34110-3, 2003.
  • Barrientos A, Korr D, Barwell KJ, Sjulsen C, Gajewski CD, Manfredi G, Ackerman S, Tzagoloff A: MTG1 codes for a conserved protein required for mitochondrial translation, Mol Biol Cell. 14(6):2292-302, 2003.
  • Ackerman SH: Atp11p and Atp12p are chaperones for F(1)-ATPase biogenesis in mitochondria, Biochim Biophys Acta. 1555(1-3):101-5, 2002.
  • Sheluho D, Ackerman SH: An accessible hydrophobic surface is a key element of the molecular chaperone action of Atp11p, J Biol Chem. 276(43):39945-9, 2001.
  • Wang ZG, White PS, Ackerman SH: Atp11p and Atp12p are assembly factors for the F(1)- ATPase in human mitochondria, J Biol Chem. 276(33):30773-8, 2001.
  • Wang ZG, *Sheluho D, Gatti DL, Ackerman SH: The alpha-subunit of the mitochondrial F(1) ATPase interacts directly with the assembly factor Atp12p, EMBO J. 19(7):1486-93, 2000.
  • Wang ZG, Ackerman SH: The assembly factor Atp11p binds to the beta-subunit of the mitochondrial F(1)-ATPase, J Biol Chem. 275(8):5767-72, 2000.
  • Wang ZG, Schmid KJ, Ackerman SH: The Drosophila gene 2A5 complements the defect in mitochondrial F1-ATPase assembly in yeast lacking the molecular chaperone Atp11p, FEBS Lett. 452(3):305-8, 1999.
  • Gatti DL, Tarr G, Fee JA, Ackerman SH: Cloning and sequence analysis of the structural gene for the bc1-type Rieske iron-sulfur protein from Thermus thermophilus HB8, J Bioenerg Biomembr. 30(3):223-33, 1998.
  • Wang ZG, Ackerman SH: Mutational studies with Atp12p, a protein required for assembly of the mitochondrial F1-ATPase in yeast. Identification of domains important for Atp12p function and oligomerization, J Biol Chem. 273(5):2993-3002, 1998.
  • Liang Y, Ackerman SH: Characterization of mutations in the beta subunit of the mitochondrial F1-ATPase that produce defects in enzyme catalysis and assembly, J Biol Chem. 271(43):26522-8, 1996.
  • Wang ZG, Ackerman SH: Identification of functional domains in Atp11p. Protein required for assembly of the mitochondrial F1-ATPase in yeast, J Biol Chem. 271(9):4887-94, 1996.
  • White M, Ackerman SH: Bacterial production and characterization of ATP11, a yeast protein required for mitochondrial F1-ATPase assembly, Arch Biochem Biophys. 319(1):299- 304, 1995.
  • Paul MF, Ackerman S, Yue J, Arselin G, Velours J, Tzagolof A: Cloning of the yeast ATP3 gene coding for the gamma-subunit of F1 and characterization of atp3 mutants, J Biol Chem. 269(42):26158-64, 1994.
  • Ackerman SH, Martin J, Tzagoloff A: Characterization of ATP11 and detection of the encoded protein in mitochondria of Saccharomyces cerevisiae, J Biol Chem. 267(11):7386-94, 1992.
  • Vambutas A, Ackerman SH, Tzagoloff A: Mitochondrial translational-initiation and elongation factors in Saccharomyces cerevisiae, Eur J Biochem. 201(3):643-52, 1991.
  • Bowman S, Ackerman SH, Griffiths DE, Tzagoloff A: Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase, J Biol Chem. 266(12):7517-23, 1991.
  • Ackerman SH, Gatti DL, Gellefors P, Douglas MG, Tzagoloff A: ATP13, a nuclear gene of Saccharomyces cerevisiae essential for the expression of subunit 9 of the mitochondrial ATPase, FEBS Lett. 278(2):234-8, 1991.
  • Ackerman SH, Tzagoloff A: Identification of two nuclear genes (ATP11, ATP12) required for assembly of the yeast F1-ATPase, Proc Natl Acad Sci U S A. 87(13):4986-90, 1990.
  • Ackerman SH, Tzagoloff A: ATP10, a yeast nuclear gene required for the assembly of the mitochondrial F1-F0 complex, J Biol Chem. 265(17):9952-9, 1990. PMID: 2141026
  • Coleman PS, Ackerman S: Catalytic Cooperativity in F1-ATPase: Photoaffinity Labeling Studies with BzATP in Molecular Structure, Function, and Assembly of the ATP Synthases, Springer, 239-249, 1989.
  • Ackerman SH, Grubmeyer C, Coleman PS: Evidence for catalytic cooperativity during ATP hydrolysis by beef heart F1-ATPase. Kinetics and binding studies with the photoaffinity label BzATP, J Biol Chem. 262(28):13765-72, 1987.
  • Williams N, Ackerman SH, Coleman PS: Benzophenone-ATP: a photoaffinity label for the active site of ATPases. Methods Enzymol. 126:667-82, 1986.

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