Ph.D. University of Wisconsin, Madison, WI, 1980
Dr. Brusilow studies the biochemistry and cell biology of neurodegeneration and the inflammatory response.
Dr. Brusilow's laboratory examines the role of nitrogen metabolism in both by studying how methionine sulfoximine, a potent inhibitor of glutamine synthesis, affects neurodegeneration in the mouse model for ALS, and the inflammatory response in the mouse model for liver failure. It has been shown that treatment with methionine sulfoximine prolongs the lifespan of the ALS mouse, and it has also been shown that methionine sulfoximine can prevent inflammation and death in the mouse model for liver failure. Currently, the laboratory is studying how mouse cell biology and biochemistry is affected by this drug to produce these therapeutic effects.
Bame, M., Pentiak, P.A., Needleman, R., and Brusilow W.S.A. 2012. Effect of sex on lifespan, diseases progression, and the response to methionine sulfoximine in the SOD1 G93A mouse model for ALS. Gender Medicine 9: 524-535
Jambekar, A.A., Palma, E., Nicolosi, L., Rasola, A., Petronilli, V., Chiara, F., Bernardi, P., Needleman, R., and Brusilow, W.S.A. 2011. A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure. Liver International 31, 1209-1211.
Rasola, A., Sciacovelli, M., Chiara, G., Pantic, B., Brusilow W.S., Bernardi, P. 2010. Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. Proc. Nat. Acad. Sci. U.S.A. 107, 726-731.
Ghoddoussi, F., Galloway, M.P., Jambekar, A., Bame, M., Needleman, R., Brusilow W.S.A. 2010. Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS. J. Neurol. Sci. 290, 41-47.
Chiara, R., Castellaro, D., Marin, O., Petronilli, V., Brusilow, W.S., Juhaszova, M., Sollot, S.J., Forte, M., Bernardi, P., Rasola, A. 2008. Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS One 3, e1852.
Brusilow, W.S.A. 2006. Is Huntington's a glutamine storage disease? Neuroscientist.12,300-304. (Hypothesis)