Ladislau Kovari

Ladislau Kovari

Professor and Associate Chair

kovari@med.wayne.edu

313-993-1335

Ladislau Kovari

Position Title

Professor and Associate Chair

Education

University of Tennessee, Ph.D., 1992
Fellowships-  Purdue University, 1992-1997, Structural Biology (X-ray Crystallography)

Graduate

 Accepting new MS students in 2020?: Yes
Accepting new PhD students in 2020?: Yes

Links of Interest

Kovari Group Web Page

Kovari Group Research

Office Location

4263 Scott Hall

Research

Dr. Kovari's research involves structure of HIV and hepatitis C virus proteins by x-ray crystallography, mechanisms of viral drug resistance, and human myelin protein zero. 

Research Focus

Our laboratory performs structure-function studies of viral drug targets using structural, biochemical and computational methods. We use X-ray crystallography and molecular modeling to explore HIV drug resistance, perform structure-based drug design against viruses (HIV-1 and hepatitis C virus) and investigate the problem of molecular recognition and protein flexibility. The objective of our research is to understand and overcome the mechanisms of viral resistance in particular as it relates to HIV and HCV. To do this, we determine the crystal structures of multidrug-resistant HIV-1 protease clinical isolates in order to elucidate the mechanisms of HIV drug resistance and help design the next generation of HIV-1 protease inhibitors.

Publications

Recent publications

Structures

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