BMB Ph.D. Student
Third year student in the Ph.D. program
Biochemistry and Molecular Biology
Advisor: Dr. Ladislau Kovari
B.S. in Molecular Biology from University of Michigan
B.A. in Human Biology from University of Michigan
Office Location4263 Scott Hall
My research interests include x-ray crystallographic studies of viral proteases including Norovirus, Zika virus and Chikungunya virus, computational studies of viral protease structure, compound design and binding efficacy, structure-based drug design of inhibitors against viral proteases, and analysis of the genotypic variations in potency of viral inhibitors based on crystal structures.
- Muzzarelli, K.M. Elucidation of the norovirus GII.4 protease structure by x-ray crystallography presented at the 2017 GSRD at WSU-SOM.
- Muzzarelli, K.M., et al. (2017). 2.4A resolution structure of human Norovirus GII.4 protease.
- D. Kuiper, B., et al. (2017). Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease. RSCB PDB.
- Bai, J., et al. (2013). Evidence that the C-terminal region is involved in the stability and functionality of OprM in E. coli. Microbiological Research.
- Muzzarelli, K.M., Webster, C., Butcher, A. (2012). Combinatorial stress influences the invasive properties of cancer cells presented at the Michigan Academy of Science, Arts, and Literature under Dr. Joseph Sucic.