Kendall Muzzarelli

Kendall Muzzarelli

BMB Ph.D. Student

kmuzzare@med.wayne.edu

313-993-1335

Kendall Muzzarelli

Position Title

Third year student in the Ph.D. program

Biography

Biochemistry and Molecular Biology
Advisor: Dr. Ladislau Kovari

Education

B.S. in Molecular Biology from University of Michigan
B.A. in Human Biology from University of Michigan

Office Location

4263 Scott Hall

Research

My research interests include x-ray crystallographic studies of viral proteases including Norovirus, Zika virus and Chikungunya virus, computational studies of viral protease structure, compound design and binding efficacy, structure-based drug design of inhibitors against viral proteases, and analysis of the genotypic variations in potency of viral inhibitors based on crystal structures.

Publications

  • ¬†Muzzarelli, K.M. Elucidation of the norovirus GII.4 protease structure by x-ray crystallography presented at the 2017 GSRD at WSU-SOM.
  • Muzzarelli, K.M., et al. (2017). 2.4A resolution structure of human Norovirus GII.4 protease.
  • D. Kuiper, B., et al. (2017). Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease. RSCB PDB.
  • Bai, J., et al. (2013). Evidence that the C-terminal region is involved in the stability and functionality of OprM in E. coli. Microbiological Research.
  • Muzzarelli, K.M., Webster, C., Butcher, A. (2012). Combinatorial stress influences the invasive properties of cancer cells presented at the Michigan Academy of Science, Arts, and Literature under Dr. Joseph Sucic.

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