James Glassbrook

James Glassbrook

IM Ph.D. Student


James Glassbrook

Position Title

Fourth year student in the Ph.D. program


Immunology and Microbiology
Advisor: Dr. Heather Gibson


B.S. in Biology from University of Michigan – Flint
M.S in Immunology and Microbiology from Wayne State University

Office Location

 HWCRC Rm 515
Barbara Ann Karmanos Cancer Institute


My research interests include leveraging systems biology approaches to investigate host intrinsic mechanisms of resistance to immunotherapy during cancer treatment. Utilizing a genetically diverse mouse model our lab aims to discover biological pathways that represent novel approaches to overcoming acquired immunotherapy resistance.

Research Focus

My M.S. thesis, ‘Human Cytomegalovirus – A systems biology approach to elucidating virus: host relationships’ addresses the usefulness of these systems-level approaches in the study of HCMV. My current work is focused on utilizing single-cell RNA sequencing as a means to investigate multiple facets of skin immunology, cancer immunology, and innate immunity. These include: 1) the characterization of murine epidermal immune cell subsets and applying trajectory mapping techniques to track their development during early life, 2) examining intratumoral transcriptome heterogeneity of tumor infiltrating lymphocytes and tumor cells in both squamous cell carcinoma and small cell carcinoma of the bladder, and 3) characterizing and exploring the development of murine Natural Killer T cells.

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