Shichao Wu
Biography
Biochemistry and Molecular Biology
Advisor: Dr. Li
Education
Bachelor's degree: Biotechnology, Shandong First Medical University, China, 2007.9-2011.6
Master’s degree: Genetics, Southeast University, China, 2011.9-2014.6
Research
My research interests include:
1. The designing and the characteristics of new aneurysm rupture mouse model caused by FBN1 nonsense mutation.
2. The mechanisms of aneurysm rupture caused by FBN1 nonsense mutation.
3. The screening and identification of the diagnostic markers for aneurysm progression and rupture.
4. The screening and identification of the therapeutical targets for preventing FBN1 mutation induced Marfan aneurysm rupture.
5. The non-coding RNAs including miRNAs and licRNAs in Marfan aneurysm.
Publications
1) Zhang, N*., X. Lu*, S. Wu*, X. Li, J. Duan, C. Chen, W. Wang, H. Song, J. Tong, S. Li, Y. Liu, X. Kang, X. Wang and F. Han (2018). "Intrastriatal transplantation of stem cells from human exfoliated deciduous teeth reduces motor defects in Parkinsonian rats." Cytotherapy 20(5): 670-686.
2) Wenjun Wang; Sen Lu; Shichao Wu; Fengqin Miao;Ning Pan;Jianqiong Zhang(2016)." A novel real-time quantitative PCR method for analyzing HLA-C allele expression level". Chinese Journal of Immunology; (12): 1165-1170
3) Pan, N., S. Lu, W. Wang, F. Miao, H. Sun, S. Wu, D. Nan, J. Qiu, J. Xu and J. Zhang (2018). "Quantification of classical HLA class I mRNA by allele-specific, real-time polymerase chain reaction for most Han individuals." HLA 91(2): 112-123
4) Han, F., D. A. Grimes, F. Li, T. Wang, Z. Yu, N. Song, Shichao Wu, L. Racacho and D. E. Bulman (2016). "Mutations in the glucocerebrosidase gene are common in patients with Parkinson's disease from Eastern Canada." Int J Neurosci 126(5): 415-421.
5) Fabin Han, Chao Chen, Wei Wang, Hao Song, Sen Li, Jing Duan, Xianjie Lu, Shichao Wu, Nan Zhang, Qingfa Chen,Yan Wang, Shuwei Liu, Chongluo Fu, Chengbiao Lu and Paul Lu (2015)."Human umbilical cord-derived mesenchymal stromal cells ameliorated motor defects of 6-OHDA-induced rat model of Parkinson’s disease". Oncotarget.
6) Chen Q, Liu J, Sawada T, Wei C, Wu S, Han F (2020). "Possible role of EphA4 and VEGFR2 interactions in neural stem and progenitor cell differentiation" [J]. Experimental and therapeutic medicine, 19(3): 1789-96.
7) Zhang A, Ma S, Yuan L, Wu S, Liu S, Wei X, Chen L, Ma C, Zhao H (2020). "Knockout of miR-21-5p alleviates cartilage matrix degradation by targeting Gdf5 in temporomandibular joint osteoarthritis" [J]. Bone & joint research, 9(10): 689-700.
8) Shixing Ma, Aobo Zhang, Xiaole Li, Shizhou Zhang, Shaopeng Liu, Haoming Zhao, Shichao Wu, Lei Chen, Chuan Ma, Huaqiang Zhao (2020) "MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1". [J]. Arthritis research & therapy, 22(1): 99.
9) Jianpu Zheng, Xiangqin He, Fang Liu, Shuping Yin, Shichao Wu, Maozhou Yang, Jiawei Zhao, Xiaohua Dai, Hong Jiang, Luyi Yu, Donghong Ju, Claire Li, Leonard Lipovich, Youming Xie, Kezhong Zhang, Hui J. Li, Jiliang Zhou, Li Li (2020). "YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation" [J]. Scientific reports, 10(1): 21781.
10). Seeburun S, Wu S, Hemani D, Pham L, Ju D, Xie Y, Kata P, Li L. Insights into elastic fiber fragmentation: Mechanisms and treatment of aortic aneurysm in Marfan syndrome. Vascul Pharmacol. 2023 Aug 26;153:107215. doi: 10.1016/j.vph.2023.107215. Epub ahead of print. PMID: 37640090.